Manfredi M., Mele F., Garrou D., Walz J., Fütterer J. J., Russo F., Vassallo L., Villers A., Emberton M., Valerio M.   Multiparametric prostate MRI: technical conduct, standardized report and clinical use. A narrative review.  Minerva Urol Nefrol.  2017
Leroy V., Templier C., Faivre J. B., Scherpereel A., Fournier C., Mortier L., Wemeau-Stervinou L.   Pembrolizumab-induced pneumonitis.  ERJ Open Res.  2017 ;3
Leroy H. A., Vermandel M., Vignion-Dewalle A. S., Leroux B., Maurage C. A., Duhamel A., Mordon S., Reyns N.   Interstitial photodynamic therapy and glioblastoma: Light fractionation in a preclinical model.  Lasers Surg. Med..  2017 ;49 :506-515
Leroy H. A., Vermandel M., Leroux B., Duhamel A., Lejeune J. P., Mordon S., Reyns N.   MRI assessment of treatment delivery for interstitial photodynamic therapy of high-grade glioma in a preclinical model.  Lasers Surg Med.  2017

BACKGROUND: High-grade gliomas are primary brain tumors that have shown increasing incidence and unfavorable outcomes. Local control is crucial to the management of this pathology. Photodynamic therapy (PDT), based on the light-induced activation of a photosensitizer (PS), achieves local treatment by inducing selective lesions in tumor tissue. OBJECTIVES: Previous studies have reported the outcomes of PDT for glioblastoma via immunohistological data. Our study aimed to evaluate MRI findings, including diffusion, and perfusion sequences, compared with immunohistological data from the same population to address the efficiency of light fractionation. MATERIALS AND METHODS: Twenty-six "nude" rats grafted with human U87 cells into the right putamen underwent PDT. After PS precursor (5-ALA) intake, an optical fiber was introduced into the tumor. The rats were randomized into the following groups: those without illumination and those that received two or five fractions of light. Treatment effects were assessed with early high-field MRI to measure the volume of necrosis and edema using diffusion and perfusion sequences; the MRI results were compared with immunohistology results, including necrosis and apoptosis markers. RESULTS: Elevated diffusion values were observed on MRI in the centers of the tumors of the treated animals, especially in the 5-fraction group (P < 0.01). Perfusion was decreased around the treatment site, especially in the 5-fraction group (P = 0.024). The MRI findings were consistent with previously published histological data. The median volume of necrosis was significantly different between the sham group and treated groups, 0 mm(3) versus 2.67 mm(3) , P < 0.001. The same trend was previously observed in histology data when grading the absence or presence of necrosis and when the presence of necrosis was significantly more predominant for the treated group than for the untreated group (P < 001). Additionally, cell death represented by apoptosis marker data (TUNEL method) was significantly higher in the 5-fraction group than in the 2-fraction group (P = 0.01). CONCLUSION: Diffusion and perfusion MRI revealed histological lesions. Interstitial PDT (iPDT) induced specific lesions in the tumor tissue, which were observed with MRI and confirmed by histopathological analysis. Thus, MRI may provide a non-invasive and reliable tool to assess treatment outcomes after PDT. Lasers Surg. Med. (c) 2017 Wiley Periodicals, Inc.

Lemaitre L., Berliet A., Maury S., Rivallan M.   Surface modifications of cobalt Fischer Tropsch catalyst followed by operando DRIFT and chemometrics.  Catal. Today.  2017 ;283 :172-175
Le Rhun E., Duhamel M., Wisztorski M., Gimeno J. P., Zairi F., Escande F., Reyns N., Kobeissy F., Maurage C. A., Salzet M., Fournier I.   Evaluation of non-supervised MALDI mass spectrometry imaging combined with microproteomics for glioma grade III classification.  BBA-Proteins Proteomics.  2017 ;1865 :875-890
Kluger N., Lebbe C., Grange F., Mortier L., Robert C.   Dermatological oncology: advanced melanoma, side effects of anti-PD1, place of monotherapy in the first line, treatment of metastatic melanoma.  Ann. Dermatol. Venereol..  2017 ;144 :S11-S14
Kharroubi Lakouas D., Huglo D., Mordon S., Vermandel M.   Nuclear medicine for photodynamic therapy in cancer: Planning, monitoring and nuclear PDT.  Photodiagnosis Photodyn. Ther..  2017 ;18 :236-243
Kerbage Y., Betrouni N., Collinet P., Azaïs H., Mordon S., Dewalle-Vignion A. S., Merlot B.   Laser interstitial thermotherapy application for breast surgery: Current situation and new trends.  Breast.  2017 ;33 :145-152
Helfrich O., Puech P., Betrouni N., Pinçon C., Ouzzane A., Rizk J., Marcq G., Randazzo M., Durand M., Lakroum S., Leroy X., Villers A.   Quantified analysis of histological components and architectural patterns of gleason grades in apparent diffusion coefficient restricted areas upon diffusion weighted MRI for peripheral or transition zone cancer locations.  J Magn Reson Imaging.  2017 ;46 :1786-1796