Chudzinski A., Collinet P., Flamand V., Rubod C.   Ureterovesical reimplantation for ureteral deep infiltrating endometriosis: A retrospective study.  J. Gynecol. Obstet. Hum. Reprod..  2017 ;46 :229-233

INTRODUCTION AND HYPOTHESIS: Symptoms of endometriosis of the urinary tract consist of nonspecific signs that are often trivialized. However, late diagnosis may be responsible for an upstream impact. The aim of this study is to describe a population of patients who received ureterovesical reimplantation for deep infiltrating endometriosis. We evaluate the preoperative clinical and radiological symptoms and long-term surgical outcomes. METHODS: All the endometriotic patients who underwent ureterovesical reimplantation at Lille university hospital between 2003 and 2013 were included retrospectively. RESULTS: Seventeen patients were included. Urological symptoms of endometriosis were present in 53% of patients and 29% had a history of urological surgery. Delay between diagnosis and ureteral reimplantation was 64+/-65 months on average. Forty-seven percent of patients had urinary functional symptoms consisting mainly of lower back pain. The ureteral lesion was known preoperatively and associated with hydroureteronephrosis in 82% of cases. Thirty-five percent of patients had renal atrophy and renal function was impaired in 23% of cases. Mean follow-up was 45+/-27 months. Forty-one percent of patients presented at least one immediate postoperative complication-fistula, postoperative infection or nerve compression. Also, urinary functional symptoms, dyspareunia and dysmenorrhea were maintained in 47%. CONCLUSION: Ureterovesical reimplantation in a context of endometriosis is major surgery with frequent complications. It requires close collaboration between gynecologists, radiologists and urologists. Prior comprehensive patient information is essential. Diagnosis and early treatment of ureteral endometriosis lesions should help reduce the morbidity of this disease.

Chen R., Sjoberg D. D., Huang Y., Xie L., Zhou L., He D., Vickers A. J., Sun Y.   Prostate Specific Antigen and Prostate Cancer in Chinese Men Undergoing Initial Prostate Biopsies Compared with Western Cohorts.  J. Urol..  2017 ;197 :90-96

PURPOSE: We determined the characteristics of Chinese men undergoing initial prostate biopsy and evaluated the relationship between prostate specific antigen levels and prostate cancer/high grade prostate cancer detection in a large Chinese multicenter cohort. MATERIALS AND METHODS: This retrospective study included 13,904 urology outpatients who had undergone biopsy for the indications of prostate specific antigen greater than 4.0 ng/ml or prostate specific antigen less than 4.0 ng/ml but with abnormal digital rectal examination results. The prostate specific antigen measurements were performed in accordance with the standard procedures at the respective institutions. The type of assay used was documented and recalibrated to the WHO standard. RESULTS: The incidence of prostate cancer and high grade prostate cancer was lower in the Chinese cohort than the Western cohorts at any given prostate specific antigen level. Around 25% of patients with a prostate specific antigen of 4.0 to 10.0 ng/ml were found to have prostate cancer compared to approximately 40% in U.S. clinical practice. Moreover, the risk curves were generally flatter than those of the Western cohorts, that is risk did not increase as rapidly with higher prostate specific antigen. CONCLUSIONS: The relationship between prostate specific antigen and prostate cancer risk differs importantly between Chinese and Western populations, with an overall lower risk in the Chinese cohort. Further research should explore whether environmental or genetic differences explain these findings or whether they result from unmeasured differences in screening or benign prostate disease. Caution is required for the implementation of prostate cancer clinical decision rules or prediction models for men in China or other Asian countries with similar genetic and environmental backgrounds.

Cartier H., Maire C.   PR-PDT, OPTIMISATION BY NAFL AND IPL WITH 5ALA LIPOSOMIAL SOLUTION.  Lasers Surg. Med..  2017 ;49 :436-436
Carlino M., Robert C., Long G., Schachter J., Arance A., Grob J. J., Mortier L., Daud A., McNeil C., Mlotem, Larkin J., Lorigan P., Neyns B., Blank C., Petrella T., Hamid O., Zhou H., Moreno B. H., Ibrahim N., Ribas A.   Long-Term Outcomes in Patients with Ipilimumab-Naive Advanced Melanoma in the Phase 3 Keynote-006 Study Who Completed Pembrolizumab Treatment.  Asia-Pac. J. Clin. Oncol..  2017 ;13 :50-51
Butler M., Hamid O., Ribas A., Hodi F. S., Walpole E., Dauad A., Arance A., Brown E., Hoeller C., Mortier L., Schachter J., Long J., Ebbinghaus S., Ibrahim N., Robert C.   Efficacy of pembrolizumab in patients with advanced mucosal melanoma enrolled in the KEYNOTE-001, 002, and 006 studies.  Eur. J. Cancer.  2017 ;72 :S123-S123
Boury S., Ernst O.   Place of the CT scan in the imaging of primary hyperparathyroidism.  Med. Nucl.-Imag. Fonct. Metab..  2017 ;41 :322-328
Bendifallah S., Ouldamer L., Lavoue V., Canlorbe G., Raimond E., Coutant C., Graesslin O., Touboul C., Collinet P., Daraï E., Ballester M.   Patterns of recurrence and outcomes in surgically treated women with endometrial cancer according to ESMO-ESGO-ESTRO Consensus Conference risk groups: Results from the FRANCOGYN study Group.  Gynecol. Oncol..  2017 ;144 :107-112

OBJECTIVES: The purpose of this study was to analyse the endometrial cancer (EC) patterns of recurrence based on a large French multicentre database according to ESMO-ESGO-ESTRO classification. METHODS: Data of women with histologically proven EC who received primary surgical treatment between January 2001 and December 2012 were retrospectively abstracted from seven institutions with prospectively maintained databases. The endpoints were recurrence, recurrence free survival (RFS) and overall survival (OS). Time to the first EC recurrence in a specific site was evaluated by using cumulative incidence analysis (Gray's test). RESULTS: Data from 829 women were analysed in whom recurrences were observed in 176 (21%) with a median and mean time to recurrence of 13 and 19.5months, respectively. High (35%) and high-intermediate risk groups (16%) were associated with higher recurrence rates compared with low (9%) and intermediate (9%) risk patients (p<0.0001). Women with high risk EC had a higher 5-year cumulative incidence of distant recurrence (20.7%) than women with high-intermediate, intermediate and low risk EC (5.6%, 3.5%, 3.3%), (p<0.001), respectively. Women with high risk and high-intermediate risk EC had a higher 5-year cumulative incidence of loco-regional recurrence (24.3% and 16.6%, respectively) than women with intermediate and low risk EC (6.6% and 6.5%, respectively), (p<0.001). CONCLUSIONS: We report specific time and site patterns of first recurrence according to the ESMO/ESGO/ESTRO classification. Sites and hazard rates for recurrence differ widely between subgroups over time. Defining patterns of EC recurrence may provide useful information for developing follow-up recommendations and designing therapeutic approaches.

Azaïs H., Leroy A., Ghesquiere L., Deruelle P., Hanssens S.   Effects of adipokines and obesity on uterine contractility.  Cytokine Growth Factor Rev..  2017 ;34 :59-66

Obesity is a major public health problem. The prevalence of obesity has significantly increased in developed countries, particularly in France with an overall increase of 76% over the last 15 years. In pregnant women, obesity is associated with alterations in the quality of labor, such as delayed onset of labor, a higher rate of prolonged pregnancies, prolonged labor, and higher oxytocin requirements. There is also an increased prevalence of Cesarean sections, particularly during the active phase of labor, and perinatal complications (postpartum hemorrhage). It seems that some of these functional changes and their consequences can be attributed to a disruption of hormonal balance encountered in obese women and involving adipokines (apelin, ghrelin, visfatin, leptin), but also to the interactions between adipose tissue and the "oxytocin (OT) - oxytocin receptor (OTR)". In this review, we detailed mechanisms to understand the impact of specific metabolic alterations in obesity on uterine contractility. Better knowledge of the impact of obesity on labor and delivery pathophysiology should strengthen the prevention of obesity in women of childbearing age and provide a suitable and effective management. The beneficial effect of weight loss and exercise in non-pregnant women on the correction of metabolic disorders secondary to obesity should be studied in populations of overweight women to demonstrate its effectiveness.

Azais H., Estevez J. P., Kerbage Y., Mordon S., Collinet P.   HOW TO DEAL WITH MICROSCOPIC PERITONEAL METASTASES OF EPITHELIAL OVARIAN CANCER?.  Int. J. Gynecol. Cancer.  2017 ;27 :1415-1415