Dupont C., Mordon S., Deleporte P., Reyns N., Vermandel M.   A novel device for intraoperative photodynamic therapy dedicated to glioblastoma treatment.  Future Oncol.  2017 ;13 :2441-2454

AIM: Photodynamic therapy (PDT) appears to be a valuable new treatment modality for cancer therapy. Studies have reported successful application of PDT for glioblastoma. Here, we introduce a new device dedicated to intraoperative PDT delivered early after fluoro-guided resection combined with a transfer function that determines the treatment time based on the size of the surgical resection cavity. MATERIALS & METHODS: First, we describe the device, which is composed of a trocar, a balloon filled with a diffusing solution, and a fiber guide in which a cylindrical light diffuser is inserted. Ex vivo experiments were performed to measure the fluence rate inside biological tissues. A calibration factor was defined to convert power measurements into fluence rate values. Calf brains were used to simulate light propagation in human brain tissue, and the photosensitizer administration effect on optical properties was discussed. The temperature elevation during illumination was evaluated. RESULTS: Light power was measured in tissues surrounding the device during ex vivo experiments. Using the previously characterized calibration factor, power measurements were converted to fluence rate values to obtain the transfer function. No thermal elevation was observed during a 2-h temperature test, and the impact of protoporphyrin IX on brain optical properties was considered negligible. CONCLUSION: A discussion of experimental precision is presented. The light duration determined by the abacus had a standard deviation of <1 min. This value is weak compared with the total illumination time necessary to treat one patient. The main advantage of our device lies in its straightforward implementation of intraoperative PDT for neurosurgery with acceptable dosimetry and easy treatment time.

Dupont C., Betrouni N., Mordon S. R., Reyns N., Vermandel M.   5-ALA Photodynamic Therapy in Neurosurgery, Towards the Design of a Treatment Planning System: A Proof of Concept.  IRBM.  2017 ;38 :34-41
Desvignes C., Abirached H., Templier C., Drumez E., Lepesant P., Desmedt E., Mortier L.   BRAF inhibitor discontinuation and rechallenge in advanced melanoma patients with a complete initial treatment response.  Melanoma Res..  2017 ;27 :281-287
De Wolf J., Bellier J., Lepimpec-Barthes F., Tronc F., Peillon C., Bernard A., Le Rochais J. P., Tiffet O., Sage E., Chapelier A., Porte H.   Exhaustive preoperative staging increases survival in resected adrenal oligometastatic non-small-cell lung cancer: a multicentre studyaEuro.  Eur. J. Cardio-Thorac. Surg..  2017 ;52 :698-703
de Montalembert M., Ribeil J. A., Brousse V., Guerci-Bresler A., Stamatoullas A., Vannier J. P., Dumesnil C., Lahary A., Touati M., Bouabdallah K., Cavazzana M., Chauzit E., Baptiste A., Lefebvre T., Puy H., Elie C., Karim Z., Ernst O., Rose C.   Cardiac iron overload in chronically transfused patients with thalassemia, sickle cell anemia, or myelodysplastic syndrome.  PLoS One.  2017 ;12
Dadoun Y., Azaïs H., Keller L., d'Orazio E., Collinet P., Decanter C.   Systematic proposal of fertility preservation by mature oocyte cryopreservation for recurrent benign ovarian tumors.  Gynecol. Obstet. Fertil. Senol..  2017 ;45 :359-365
Dabi Y., Uzan J., Bendifallah S., Ouldamer L., Lavoué V., Canlorbe G., Raimond E., Coutant C., Graesslin O., Collinet P., Bricou A., Daraï E., Ballester M., Haddad B., Touboul C.   Prognostic value of local relapse for patients with endometrial cancer.  Eur J Surg Oncol.  2017
Cornelis F., Ambrosetti D., Rocher L., Derchi L. E., Renard B., Puech P., Claudon M., Rouvière O., Ferlicot S., Roy C., Yacoub M., Grenier N., Bernhard J. C.   CT and MR imaging features of mucinous tubular and spindle cell carcinoma of the kidneys. A multi-institutional review.  Eur. Radiol..  2017 ;27 :1087-1095
Chudzinski A., Collinet P., Flamand V., Rubod C.   Ureterovesical reimplantation for ureteral deep infiltrating endometriosis: A retrospective study.  J Gynecol Obstet Hum Reprod.  2017 ;46 :229-233
Chenoz L., Phelippeau J., Barranger E., Bourdel N., Brun J. L., Chereau E., Collinet P., Coutant C., Darai E., Deffieux X., Gautier T., Golfier F., Huchon C., Ouldamer L., Rouzier R., Koskas M.   Evaluation and Selection of Quality Indicators for the Management of Endometrial Cancer.  Int. J. Gynecol. Cancer.  2017 ;27 :979-986