Basset-Seguin N., Dupuy A., Saiag P., Dalac-Rat S., Guillot B., Routier E., Leccia M. T., Duhamel A., Mirabel X., Benbouta I., Mirakovska L., Meddour D., Dib M., Mahmoudi A., Guerreschi P., Mortier L.   VISMONEO - a phase II study assessing vismodegib in the neoadjuvant treatment of locally advanced basal cell carcinoma - patients characteristics.  Melanoma Res..  2016 ;26 :E71-E72
Rouprêt M., Neuzillet Y., Masson-Lecomte A., Colin P., Compérat E., Dubosq F., Houédé N., Larré S., Pignot G., Puech P., Roumiguié M., Xylinas E., Méjean A.   [CCAFU french national guidelines 2016-2018 on bladder cancer].  Prog. Urol..  2016 ;27 Suppl 1 :S67-S91
Picry A., Bonne N. X., Ding J., Aboukais R., Lejeune J. P., Baroncini M., Dubrulle F., Vincent C.   Long-term Growth Rate of Vestibular Schwannoma in Neurofibromatosis 2: A Volumetric Consideration.  Laryngoscope.  2016 ;126 :2358-2362

OBJECTIVES/HYPOTHESIS: To determine the long-term growth rate of vestibular schwannoma (VS) in neurofibromatosis type 2 (NF2) patients based on volumetric measurements. STUDY DESIGN: Retrospective review. METHODS: We retrospectively reviewed magnetic resonance imaging (MRI) scans acquired from patients with NF2 from 1999 to 2013. Patients with an annual radiologic follow-up over at least 3 consecutive years were included. Volumetric VS growth was prospectively measured using a three-dimensional imaging workstation and through manual contouring of the lesion. Time to tumor progression was assessed according to the Response Evaluation in Neurofibromatosis and Schwannomatosis Tumor Measurement Group. RESULTS: Eighteen patients presenting with a total of 26 VSs were included. The mean age at diagnosis was 26.1 years (range, 7 to 49 years). One hundred five MRI scans were analyzed during a median radiological follow-up of 5.6 years (range, 3 to 12 years). The annual volume and diameter growth rates were respectively 218.3 mm(3) /yr (range, -10 to 1,250 mm(3) /yr) and 0.9 mm/yr (range, -0.5 to 4.5 mm/yr). Time to tumor progression was 3 years (median survival). There was a weak correlation between volumetric and linear measurements (P < .0001, linear regression, n = 26, r(2) = 0.58). Among the 26 VSs, 76.9% (20/26) showed progression (VS growth more than 20%), 19.2% were stable, and 3.9% (1/26) exhibited shrinkage (spontaneous regression of more than 20% of the initial volume). CONCLUSIONS: This study helps to assess the long-term growth profile of VS in a population of NF2 patients with untreated VS. These data could help to better acknowledge VS natural growth history. LEVEL OF EVIDENCE: 4 Laryngoscope, 126:2358-2362, 2016.

Waibel J. S., Mi Q. S., Ozog D., Qu L., Zhou L., Rudnick A., Al-Niaimi F., Woodward J., Campos V., Mordon S.   Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression.  Lasers Surg. Med..  2016 ;48 :238-244

BACKGROUND AND OBJECTIVE: Laser-assisted drug delivery is an emerging technology to achieve greater penetration by existing topical medications to reach desired targets in the tissue. The objective of this research was to study whether laser-assisted delivery of Vitamin C, E, and Ferulic immediately postoperatively of fractional ablative laser could improve wound healing. Secondary objectives were to evaluate the potential molecular markers involved in this wound-healing process. STUDY DESIGN/MATERIAL AND METHODS: A double blinded, prospective, single center, randomized split face trial of Vitamin C, E, and Ferulic topical formula #740019 to decrease postoperative recovery time in fractional ablative laser resurfacing for photo damage. Fifteen healthy men and women of ages 30-55 years were treated with the Vitamin C, E, and Ferulic acid serum to one side of face and vehicle to the other side of face, within 2 minutes immediately after fractional ablative CO2 laser surgery and daily during the healing process. Patients were evaluated daily on days 1-7 using photographs, patient questionnaires, and molecular evaluation. RESULTS: Clinically, postoperative Vitamin C, E, and Ferulic delivery resulted in decreased edema versus vehicle on postoperative day 7 and decreased erythema versus vehicle on postoperative days 3 and 5. Molecularly, the expression of basic fibroblast growth factor (bFGF) was significantly increased at day 5 on the lesion treated with Vitamin C, E, and Ferulic acid serum compared to vehicle control on the other side. CONCLUSION: This is first study to show that Vitamin C, E, and Ferulic acid correlate with more rapid wound healing post-fractional ablative laser. Elevated bFGF could be involved in the Vitamin C, E, and Ferulic acid-induced rapid wound healing.

Vignion A. S., Betrouni N., Dupont C., Tylcz J. B., Vicentini C., Mordon S.   COMPARISON OF TWO FLUENCE RATES IN THE PHOTODYNAMIC TREATMENT OF ACTINIC KERATOSIS USING MATHEMATICAL MODELING.  Lasers Surg. Med..  2016 ;48 :50-51
Vicentini C., Tylcz J. B., Maire C., Betrouni N., Mortier L., Mordon S.   PHASE II STUDY EVALUATING THE NON-INFERIORITY OF THE DEVICE FLEXITHERALIGHT (R) COMPARED TO CONVENTIONAL PDT.  Lasers Surg. Med..  2016 ;48 :51-51
Vicentini C., Carpentier O., Tylcz J. B., Betrouni N., Mortier L., Mordon S.   TREATMENT OF A VULVAR PAGET DISEASE BY PHOTODYNAMIC THERAPY WITH A NEW LIGHT EMITTING FABRIC BASED DEVICE.  Lasers Surg. Med..  2016 ;48 :61-62
Vasseur A. S., Hazzan M., Lemaitre L., Kilani M., Anglicheau D., Caillard-Ohlmann S., Choukroun G., Godin M., de Ligny B. H., Mousson C., Merville P., Vigneau C., Glowacki F., Noel C., Frimat M.   TRANSPLANT RENAL ARTERY STENOSIS : A CASE SERIES.  Nephrol. Dial. Transplant..  2016 ;31 :1585-1585
Uyttenhove F., Langlois C., Collinet P., Rubod C., Verpillat P., Bigot J., Kerdraon O., Faye N.   Deep infiltrating endometriosis: Should rectal and vaginal opacification be systematically used in MR imaging?.  Gynecol. Obstet. Fertil..  2016 ;44 :322-328

OBJECTIVES: To evaluate the interest of rectal and vaginal filling in vaginal and recto-sigmoid endometriosis with MR imaging. To compare the results between a senior and a junior radiologist review. METHODS: Sixty-seven patients with clinically suspected deep infiltrating endometriosis were included in our MRI protocol consisting of repeated T2-weigthed sequences (axial and sagittal) before and after rectal and vaginal marking with ultrasonography gel. Vaginal and recto-sigmoid endometriosis lesions were analyzed before and after opacification. The inter-reader agreement between senior and junior scores was studied. RESULTS: Concerning vaginal and muscularis and beyond colonic involvement, no significant difference (P=0.32) was observed and the inter-reader agreement was excellent (K=0.96 and 0.97 respectively). Concerning serosa colonic lesions, a significant difference was observed (P=0.01) and the inter-reader agreement was poor (K=0). CONCLUSIONS: Rectal and vaginal filling in endometriosis staging with MRI is not necessary no matter the reader experiment.

Truant S., Baillet C., Deshorgue A. C., Leteurtre E., Hebbar M., Ernst O., Huglo D., Pruvot F. R.   Drop of Total Liver Function in the Interstages of the New Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Technique: Analysis of the "Auxiliary Liver'' by HIDA Scintigraphy.  Ann. Surg..  2016 ;263 :e33-e34